CpG/DNA methylation

Posted on Fri 09 March 2018 in Fundamentals • Tagged with CpG methylation, methyl-induced shape-readout, methyl-DNAshape

CpG methylation

CpG methylation is an epigenetic modification on DNA. At the molecular level, CpG methylation involves the addition of a methyl (CH₃) group on the C5 atom of cytosine, yeilding 5-methylcytosine (5mC). Although the change is very small, but cumulative effect is profound, for example X-chromosome inactivation. Recent …